Comorbidities in palmoplantar pustulosis: a Swedish population-based register study
Löfvendahl S, Norlin JM, Schmitt-Egenolf M
Palmoplantar pustulosis (PPP), which can occur with or without psoriasis vulgaris (PV), is a chronic relapsing skin condition characterized by sterile pustules on the palm and soles. This disease is often seen with psoriasis vulgaris (PV). There is little research on comorbidities in PPP. In the present study, researchers at IHE investigated comorbidities in people with PPP compared to i) matched controls from the general population, and ii) matched PV controls.
In the Swedish National Patient Register (NPR) we identified people with PPP (N=15 564) which we matched (1:3) to people with PV and (1:5) to people from the general population using the Total Population Register. Odds ratios (ORs) for comorbidities identified in the NPR were estimated by logistic regression.
Compared to the general population, people with PPP had significantly higher odds for 32 of 35 evaluated conditions, including allergic contact dermatitis (OR:6.25), chronic obstructive pulmonary disease (COPD; OR:2.54) and Crohn’s disease (OR:2.20). The overall comorbidity burden was similar for people with PPP (with or without a diagnosis of psoriasis vulgaris) compared to PV controls, however, significantly higher odds ratios were observed for several individual conditions including apical periodontitis (OR: 1.75), allergic contact dermatitis (OR: 1.61), celiac disease (OR: 1.55), peripheral vascular disease (1.50) and COPD (OR:1.48). In contrast, odds were significantly lower for some conditions including liver disease (OR:0.49) and non-alcoholic fatty liver disease, OR:0.66) and psoriatic arthritis (OR:0.74). In conclusion, people with PPP have a high comorbidity burden compared to the general population and a different comorbidity profile than people with PV.
British Journal of Dermatology, 2023;, ljad134
DOI:10.1093/bjd/ljad134
