A Real-World Clinical Trial Evaluating Satisfaction and Experiences with a Dexamethasone Mouth Film Compared to Corticosteroid Tablets as Rescue Medication for Moderate to Severe Acute Allergic Reactions

Bjermer L, Tornling G, Kereki J, Wahlberg K, Javizian B, Hjelmgren J

This is the first of two complementary studies recently published in the Journal of Market Access and Health Policy examining patient preferences for a corticosteroid mouth-dissolving film compared with conventional tablets for moderate to severe acute allergic reactions.

The study was a non-randomized, open-label, low-interventional real-world clinical trial in which patients had access to both treatments over a six-month period. The mouth film was perceived as more accessible and secure than tablets, improved medication-carrying behaviour, and was chosen in 16 of 18 reported treatment episodes. After six months, 69% of participants preferred the mouth film, compared with only 3% who preferred tablets, while 28% were indifferent.

The second study was a more in-depth analysis of patient preferences. Together, the two studies suggest that mode of administration matters to patients and can influence both treatment preferences and practical aspects of medication use, such as perceived security and medication carriage in clinical practice.

Download the publication for the clinical trial (first study)

Read more about the second study and download the publication

Journal of Market Access & Health Policy 2026, 14, 43, 1-16.
https://www.mdpi.com/2001-6689/14/3/43