Comorbidities in patients with generalized pustular psoriasis- a nationwide population-based register study

Löfvendahl S, Norlin JM, Schmitt-Egenolf M

Generalized pustular psoriasis (GPP) is a rare and severe type of pustular psoriasis. We have investigated whether people with GPP have a higher occurrence of other diseases, i.e. a higher comorbidity burden, compared to people from the general population and to people with the more common skin disease psoriasis vulgaris.

For this purpose, we used data from the Swedish National Patient Register (NPR). The study included 1,093 people with GPP, 5,399 controls from the general population and 3,252 controls with psoriasis vulgaris. Relevant comorbidities were identified in the literature and the occurrences were compared between people with GPP and controls using statistical methods.

The results showed that 70% of people with GPP had any of the comorbidities, compared with 46% of controls from the general population and 63% of psoriasis vulgaris controls. The most common conditions in GPP were hypertension, psoriatic arthritis, and diabetes type 2. Conditions that were more common in GPP compared to psoriasis vulgaris included Crohn’s disease, diabetes type 2, and peptic ulcer disease.

In conclusion, the results indicated that people with GPP had an overall higher disease burden compared to the general population and a more severe comorbidity profile than patients with psoriasis vulgaris.

Read more

Journal of the American Academy of Dermatology, Oct 2022, Online ahead of print
DOI: 10.1016/j.jaad.2022.09.049