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High risk of developing dementia in Parkinson’s disease: a Swedish registry-based study

Åström DO, Simonsen J, Raket LL, Sgarbi S, Hellsten J, Hagell P, Norlin JM, Kellerborg K, Martinez-Martin P, Odin P

Motor-symptoms, such as tremor and freezing, are well known in Parkinson’s disease (PD). Non-motor symptoms inpersons living with PDare less known. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries.

Persons with Parkinson’s disease in the Swedish Parkinson’s Disease Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since diagnosis as the underlying time variable.

In this large prospective cohort study, persons with PD had almost four times higher risk of developing dementia as compared to age and sex-matched controls, a finding which remained after adjusting for potential confounders. The present results underline the high risk of dementia in PD and further emphasize the importance of developing symptomatic and ultimately disease modifying strategies to counteract this part of the non-motor symptomatology in PD.

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Scientific Reports 12, 16759 (2022)
DOI: https://doi.org/10.1038/s41598-022-21093-8